CGKII Antibody (C-term) [APR14283G]
Product Specifications
Background
Tissue Location: Highly concentrated in brain, lung and intestinal mucosa
Synonyms
CGMP-dependent protein kinase 2, cGK 2, cGK2, cGMP-dependent protein kinase II, cGKII, PRKG2, PRKGR2
Gene Name
PRKG2
Gene ID
5593
UniProt
Q13237
Chromosomal Location
Apical cell membrane; Lipid-anchor
Applications
WB, IHC-P
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Crucial regulator of intestinal secretion and bone growth (By similarity) . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity) . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity) . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity) .
Molecular Weight
87432
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality cGKII Antibody (C-term) [APR14283G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5593
Uniprot URL
https://www.uniprot.org/uniprot/Q13237
Available Sizes
Curated Selection
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