PRKX Antibody (C-term) [APR14381G]

Product Specifications

Background

Tissue Location: Widely expressed (at protein level) . Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PRKX Antibody (C-term) [APR14381G].

Synonyms

CAMP-dependent protein kinase catalytic subunit PRKX, PrKX, Protein kinase X, Protein kinase X-linked, Serine/threonine-protein kinase PRKX, Protein kinase PKX1, PRKX, PKX1

Gene Name

PRKX

Gene ID

5613

UniProt

P51817

Chromosomal Location

Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation

Applications

IHC-P

Dilution

IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular- like structure formation.