HNRPQ Antibody (C-term) [APR11136G]

Tissue Location: Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.

Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, Glycine- and tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, Synaptotagmin-binding, cytoplasmic RNA-interacting protein, SYNCRIP, HNRPQ, NSAP1

Cytoplasm. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Endoplasmic reticulum Nucleus {ECO:0000250|UniProtKB:Q7TMK9}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity) . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity) . {ECO:0000250|UniProtKB:O43390, ECO:0000250|UniProtKB:Q7TMK9} [Isoform 2]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly (A) and poly (U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HNRPQ Antibody (C-term) [APR11136G].