LTK Antibody (N-term) [APR08288G]

Product Specifications

Background

Tissue Location: Expressed in non-hematopoietic cell lines and T- and B-cell lines.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LTK Antibody (N-term) [APR08288G].

Synonyms

Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, LTK, TYK1

Gene Name

LTK

Gene ID

4058

UniProt

P29376

Chromosomal Location

Membrane; Single-pass type I membrane protein.

Applications

Dilution

WB--1:2000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.