DYRK1A Antibody (N-term) [APR11812G]
Product Specifications
Background
Tissue Location: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Synonyms
Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH
Gene Name
DYRK1A
Gene ID
1859
UniProt
Q13627
Chromosomal Location
Nucleus. Nucleus speckle {ECO:0000250|UniProtKB:Q61214}
Applications
IHC-P, WB
Dilution
WB--1:500-1:2000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity) . Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity) .
Molecular Weight
85584
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DYRK1A Antibody (N-term) [APR11812G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1859
Uniprot URL
https://www.uniprot.org/uniprot/Q13627
Available Sizes
Curated Selection
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