CSNK1G2 Antibody (C-term) [APG02815G]
Product Specifications
Background
Tissue Location: Testis.
Synonyms
Casein kinase I isoform gamma-2, CKI-gamma 2, CSNK1G2, CK1G2
Gene Name
CSNK1G2
Gene ID
1455
UniProt
P78368
Chromosomal Location
Cytoplasm, cell cortex. Cytoplasm
Applications
IHC-P, WB
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine- repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Molecular Weight
47457
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CSNK1G2 Antibody (C-term) [APG02815G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1455
Uniprot URL
https://www.uniprot.org/uniprot/P78368
Available Sizes
Curated Selection
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