RASIP1 Antibody (Center) [APR14387G]
Product Specifications
Background
Tissue Location: Highly expressed in heart. Detected at lower levels in placenta and pancreas.
Synonyms
Ras-interacting protein 1, Rain, RASIP1
Gene Name
RASIP1
Gene ID
54922
UniProt
Q5U651
Chromosomal Location
Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS
Applications
WB, IHC-P, FC
Dilution
FC--1:25 WB--1:2000 WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity) . May act as effector for Golgi-bound HRAS and other Ras- like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Molecular Weight
103457
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RASIP1 Antibody (Center) [APR14387G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=54922
Uniprot URL
https://www.uniprot.org/uniprot/Q5U651
Available Sizes
Curated Selection
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