Synphilin-1 (SNCAIP) Antibody (C-term) [APR13635G]

Product Specifications

Background

Tissue Location: Detected in brain (at protein level) . Widely expressed, with highest levels in brain, heart and placenta

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Synphilin-1 (SNCAIP) Antibody (C-term) [APR13635G].

Synonyms

Synphilin-1, Sph1, Alpha-synuclein-interacting protein, SNCAIP

Gene Name

SNCAIP

Gene ID

9627

UniProt

Q9Y6H5

Chromosomal Location

Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.