TC14012 (TFA)
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity[1][2].
Product Specifications
UNSPSC
12352209
Target
CXCR; HIV
Type
Peptides
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/tc14012-tfa.html
Solubility
H2O
Smiles
[RR-{2Nal}-CY-{Cit}-K-{Cit}-PYR-{Cit}-CR-NH2(Disulfidebridge:Cys4-Cys13)(TFAsalt)]
Molecular Formula
C92H141F3N34O21S2
Molecular Weight
2180.44
References & Citations
[1]H Tamamura, et al. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001 Jul 23;11 (14) :1897-902.|[2]Stéphanie Gravel, et al. The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. J Biol Chem. 2010 Dec 3;285 (49) :37939-43.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR4; CXCR7; HIV
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