LINGO-1 (LRRN6A) -S596 (C-term) Antibody [APR11272G]

Product Specifications

Background

Tissue Location: Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LINGO-1 (LRRN6A) -S596 (C-term) Antibody [APR11272G].

Synonyms

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a

Gene Name

Lingo1

Gene ID

235402

UniProt

Q9D1T0

Chromosomal Location

Cell membrane; Single-pass type I membrane protein

Applications

WB, IHC-P

Dilution

WB--1:1000-1:2000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity) . Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.