ANKFY1 Antibody (C-term) [APR14928G]

Product Specifications

Background

Tissue Location: High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ANKFY1 Antibody (C-term) [APR14928G].

Synonyms

Rabankyrin-5, Rank-5, Ankyrin repeat and FYVE domain-containing protein 1, Ankyrin repeats hooked to a zinc finger motif, ANKFY1, ANKHZN, KIAA1255

Gene Name

ANKFY1

Gene ID

51479

UniProt

Q9P2R3

Chromosomal Location

Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note=Also associated with endosomal membranes. Localizes to macropinosomes.

Applications

WB, IHC-P, FC

Dilution

WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI (3) P) . Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.