Phospho-MeCP2 (S423) Antibody [APG03024G]

Product Specifications

Background

Tissue Location: Present in all adult somatic tissues tested.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-MeCP2 (S423) Antibody [APG03024G].

Synonyms

Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2

Gene Name

MECP2

Gene ID

4204

UniProt

P51608

Chromosomal Location

Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.

Applications

IHC-P-Leica, WB

Dilution

IHC-P-Leica--1:500 WB--1:500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) - containing DNA, with a preference for 5-methylcytosine (5mC) .