Phospho-MeCP2 (S423) Antibody [APG03024G]
Product Specifications
Background
Tissue Location: Present in all adult somatic tissues tested.
Synonyms
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Gene Name
MECP2
Gene ID
4204
UniProt
P51608
Chromosomal Location
Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.
Applications
IHC-P-Leica, WB
Dilution
IHC-P-Leica--1:500 WB--1:500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) - containing DNA, with a preference for 5-methylcytosine (5mC) .
Molecular Weight
52441
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-MeCP2 (S423) Antibody [APG03024G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4204
Uniprot URL
https://www.uniprot.org/uniprot/P51608
Available Sizes
Curated Selection
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