Phospho-FRAP1 (T2446) Antibody [APR07148G]
Product Specifications
Background
Tissue Location: Expressed in numerous tissues, with highest levels in testis.
Synonyms
Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Gene Name
HGNC:3942
Gene ID
2475
UniProt
P42345
Chromosomal Location
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body {ECO:0000250|UniProtKB:Q9JLN9}. Microsome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity) . Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137) . Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113) {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:29750193, ECO:0000269|PubMed:30956113}
Applications
DB
Dilution
DB--1:500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
1208709812150925121509261223151012718876146518491526886215467718155456251571847018497260187620231892587520516213205375362165960423429703234297042579922726018084152688621546771818925875184972602051621321576368216596042342970412087098121509251215092612231510127188761465184915268862154677181554562515718470184972601876202318925875205162132053753621659604234297032342970425799227260180841215092512087098189258752257601522343943226924232257601522343943226924232342970423429703205162132053753630704899235249512543805521659604122315101526886215467718157184701526886218925875
Molecular Weight
288892
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-FRAP1 (T2446) Antibody [APR07148G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2475
Uniprot URL
https://www.uniprot.org/uniprot/P42345
Available Sizes
Curated Selection
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