M Sema5aAntibody (N-term) [APR11274G]
Product Specifications
Synonyms
Semaphorin-5A, Semaphorin-F, Sema F, SEMA5A, SEMAF
Gene Name
SEMA5A
Gene ID
9037
UniProt
Q13591
Chromosomal Location
Membrane; Single-pass type I membrane protein.
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity) . Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Molecular Weight
120615
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality M Sema5aAntibody (N-term) [APR11274G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=9037
Uniprot URL
https://www.uniprot.org/uniprot/Q13591
Available Sizes
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