Ifoxetine (hemisulfate)

Ifoxetine (CGP 15210G) hemisulfate is an inhibitor of 5-HT reuptake. Ifoxetine hemisulfate specifically and selectively blocks the 5-HT reuptake in the brain without affecting the 5-HT uptake processes in the periphery (blood platelets) . Ifoxetine hemisulfate inhibits the uptake of radiolabelled 5-HT into rat brain synaptosomes in vitro or ex vivo. Ifoxetine hemisulfate has antidepressant properties[1][2].

Product Specifications

CAS Number

[98518-48-0]

Product Name Alternative

CGP 15210G (hemisulfate)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgp-15210g.html

Smiles

O=S(O)(O)=O.CC(C(C)=CC=C1)=C1O[C@H]2[C@H](CNCC2)O

Molecular Formula

C13H19NO2.1/2H2O4S

Molecular Weight

270.33

References & Citations

[1]P. C. Waldmeier, et al. Ifoxetine: An Unusual 5-HT Uptake Inhibitor or an Inhibitor of 5-HT Release? Pharmacopsychiatry 1986; 19 (4) : 318-319.|[2]Delini-Stula A, et al. First clinical experience with ifoxetine, a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs. Int Clin Psychopharmacol. 1987 Jul;2 (3) :201-15.