NPRL3 Antibody (N-Term) [APR17593G]
Product Specifications
Background
Tissue Location: Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888) .
Synonyms
Nitrogen permease regulator 3-like protein, -14 gene protein, Alpha-globin regulatory element-containing gene protein, Protein CGTHBA, NPRL3, C16orf35, CGTHBA, MARE
Gene Name
HGNC:14124
Gene ID
8131
UniProt
Q12980
Chromosomal Location
Lysosome membrane. Note=Localization to lysosomes is amino acid-independent
Applications
WB
Dilution
WB--1:2000
Function
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Molecular Weight
63605
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NPRL3 Antibody (N-Term) [APR17593G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8131
Uniprot URL
https://www.uniprot.org/uniprot/Q12980
Available Sizes
Curated Selection
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