LGMN Antibody (N-term) [APR08220G]
Product Specifications
Background
Tissue Location: Ubiquitous. Particularly abundant in kidney, heart and placenta
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LGMN Antibody (N-term) [APR08220G].
Synonyms
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Gene Name
LGMN
Gene ID
5641
UniProt
Q99538
Chromosomal Location
Lysosome.
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity) . May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Molecular Weight
49411
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5641
Uniprot URL
https://www.uniprot.org/uniprot/Q99538
Available Sizes
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