STX4 Antibody (Center) [APR13589G]

Product Specifications

Background

Tissue Location: Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STX4 Antibody (Center) [APR13589G].

Synonyms

Syntaxin-4, Renal carcinoma antigen NY-REN-31, STX4, STX4A

Gene Name

STX4

Gene ID

6810

UniProt

Q12846

Chromosomal Location

Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850}

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity) . Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity) . In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity) . Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity) .