NCDN Antibody (N-term) [AMM06568G]

Tissue Location: Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine

Cytoplasm, cytosol. Endosome membrane {ECO:0000250|UniProtKB:O35095}; Lipid-anchor. Cell projection, dendrite {ECO:0000250|UniProtKB:O35095}. Cell junction, synapse, postsynapse {ECO:0000250|UniProtKB:O35095}. Note=Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation {ECO:0000250|UniProtKB:O35095}

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity) . Required for the spatial learning process. Acts as a negative regulator of Ca (2+) -calmodulin- dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NCDN Antibody (N-term) [AMM06568G].