SIB-1553A
SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2].
Product Specifications
CAS Number
191611-89-9
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sib-1553a.html
Purity
99.09
Solubility
H2O : ≥ 100 mg/mL
Smiles
OC(C=C1)=CC=C1SCCC2N(CCC2)C.[H]Cl
Molecular Formula
C13H20ClNOS
Molecular Weight
273.82
References & Citations
[1]Vernier JM, et al. 4-[[2- (1-Methyl-2-pyrrolidinyl) ethyl]thio]phenol hydrochloride (SIB-1553A) : a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1999 May 20;42 (10) :1684-6.|[2]Rao TS, et al. In vitro pharmacological characterization of (+/-) -4-[2- (1-methyl-2-pyrrolidinyl) ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 2003 Aug 15;981 (1-2) :85-98.|[3]Rao TS, et al. In vivo pharmacological characterization of (+/-) -4-[2- (1-methyl-2-pyrrolidinyl) ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies. Brain Res. 2003 Oct 3;986 (1-2) :71-81.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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