SIB-1553A

SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2].

Product Specifications

CAS Number

[191611-89-9]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sib-1553a.html

Purity

99.09

Solubility

H2O : ≥ 100 mg/mL

Smiles

OC(C=C1)=CC=C1SCCC2N(CCC2)C.[H]Cl

Molecular Formula

C13H20ClNOS

Molecular Weight

273.82

References & Citations

[1]Vernier JM, et al. 4-[[2- (1-Methyl-2-pyrrolidinyl) ethyl]thio]phenol hydrochloride (SIB-1553A) : a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1999 May 20;42 (10) :1684-6.|[2]Rao TS, et al. In vitro pharmacological characterization of (+/-) -4-[2- (1-methyl-2-pyrrolidinyl) ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 2003 Aug 15;981 (1-2) :85-98.|[3]Rao TS, et al. In vivo pharmacological characterization of (+/-) -4-[2- (1-methyl-2-pyrrolidinyl) ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies. Brain Res. 2003 Oct 3;986 (1-2) :71-81.