CLC Antibody (C-term) [APR15468G]

Product Specifications

Background

Tissue Location: Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level) . Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level) . Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level)

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLC Antibody (C-term) [APR15468G].

Synonyms

Galectin-10, Gal-10, Charcot-Leyden crystal protein, CLC, Eosinophil lysophospholipase, Lysolecithin acylhydrolase, CLC, LGALS10, LGALS10A

Gene Name

CLC

Gene ID

1178

UniProt

Q05315

Chromosomal Location

Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) .