PDE11A Antibody (N-term) [AMM07034G]
Product Specifications
Background
Tissue Location: Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level) . Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
Synonyms
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A, PDE11A
Gene Name
PDE11A
Gene ID
50940
UniProt
Q9HCR9
Chromosomal Location
Cytoplasm, cytosol.
Applications
WB, IHC-P
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Molecular Weight
104752
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PDE11A Antibody (N-term) [AMM07034G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=50940
Uniprot URL
https://www.uniprot.org/uniprot/Q9HCR9
Available Sizes
Curated Selection
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