Sudan IV
Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA) ) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections[1][2][3][4].
Product Specifications
CAS Number
85-83-6
Product Name Alternative
Solvent Red 24; C.I. 26105
UNSPSC
12171500
Hazard Statement
H317
Target
Aryl Hydrocarbon Receptor; Biochemical Assay Reagents; Cytochrome P450
Type
Dye Reagents
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sudan-iv.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL
Smiles
OC1=CC=C2C=CC=CC2=C1/N=N/C3=CC=C(/N=N/C4=CC=CC=C4C)C=C3C
Molecular Formula
C24H20N4O
Molecular Weight
380.44
Precautions
H317
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
CYP1
Frequently Asked Questions
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