KCNJ4 Antibody (N-term) [AMM06129G]

Product Specifications

Background

Tissue Location: Heart, skeletal muscle, and several different brain regions including the hippocampus

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KCNJ4 Antibody (N-term) [AMM06129G].

Synonyms

Inward rectifier potassium channel 4, HIRK2, HRK1, Hippocampal inward rectifier, HIR, Inward rectifier K (+) channel Kir23, IRK-3, Potassium channel, inwardly rectifying subfamily J member 4, KCNJ4, IRK3

Gene Name

KCNJ4

Gene ID

3761

UniProt

P48050

Chromosomal Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization.

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity) .