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KCNK1 Antibody (C-term) [AMM06133G]

Product Specifications

Background

Tissue Location: Detected in bronchial epithelial cells (PubMed:21964404) . Detected in heart left atrium and left ventricle (PubMed:17478540) . Detected in cardiac myocytes (at protein level) (PubMed:21653227) . Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed:8605869, PubMed:9362344) . Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed:11165377) Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed:17478540) . Detected in bronchial epithelial cells (PubMed:21964404) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KCNK1 Antibody (C-term) [AMM06133G].

Synonyms

Potassium channel subfamily K member 1, Inward rectifying potassium channel protein TWIK-1, Potassium channel KCNO1, KCNK1, HOHO1, KCNO1, TWIK1

Gene Name

KCNK1

Gene ID

3775

UniProt

O00180

Chromosomal Location

Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:8978667, ECO:0000305} Recycling endosome. Cell junction, synapse, synaptic cell membrane {ECO:0000250|UniProtKB:Q9Z2T2} Cytoplasmic vesicle {ECO:0000250|UniProtKB:O08581}. Perikaryon {ECO:0000250|UniProtKB:O08581}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08581}. Cell projection {ECO:0000250|UniProtKB:O08581}. Apical cell membrane; Multi-pass membrane protein. Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections. Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites Detected at the apical cell membrane in stria vascularis in the cochlea. Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear. Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3. Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (By similarity) . Detected at the apical cell membrane of bronchial epithelial cells (PubMed:21964404) {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:21964404}

Applications

WB, IHC-P

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

15820677216532272165322722431633860586989786671582067721653227224316332316981825001086231698182316981815820677204980502316981819959478

Molecular Weight

38143

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=3775

Uniprot URL

https://www.uniprot.org/uniprot/O00180

Available Sizes

Frequently Asked Questions

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