SHISA6 Antibody (N-term) [APR13308G]

Product Specifications

Background

Tissue Location: Expressed in the developing ventral mesencephalon.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SHISA6 Antibody (N-term) [APR13308G].

Synonyms

Protein shisa-6 homolog, SHISA6

Gene Name

HGNC:34491

Gene ID

388336

UniProt

Q6ZSJ9

Chromosomal Location

Membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3UH99}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q3UH99}

Applications

WB, IHC-P

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway.