SLC5A12 Antibody (C-term) [APR10131G]

Product Specifications

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SLC5A12 Antibody (C-term) [APR10131G].

Synonyms

Sodium-coupled monocarboxylate transporter 2, Electroneutral sodium monocarboxylate cotransporter, Low-affinity sodium-lactate cotransporter, Solute carrier family 5 member 12, SLC5A12, SMCT2

Gene Name

SLC5A12

Gene ID

159963

UniProt

Q1EHB4

Chromosomal Location

Apical cell membrane; Multi-pass membrane protein. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity) .

Applications

IHC-P, FC, WB

Dilution

WB--1:2000 IHC-P--1:100~500 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Acts as an electroneutral and low-affinity sodium (Na (+) ) - dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity) . Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na (+) for each lactate (By similarity) .