CLDN7 Antibody (C-term) [APR15495G]
Product Specifications
Background
Tissue Location: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions
Synonyms
Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2
Gene Name
CLDN7
Gene ID
1366
UniProt
O95471
Chromosomal Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction
Applications
WB, IHC-P, FC
Dilution
WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.
Molecular Weight
22418
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLDN7 Antibody (C-term) [APR15495G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1366
Uniprot URL
https://www.uniprot.org/uniprot/O95471
Available Sizes
Curated Selection
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