SPHK2 Antibody (C-term) [APS00021G]

Product Specifications

Background

Tissue Location: Mainly expressed in adult kidney, liver, and brain (PubMed:10751414) . Expressed in cerebral cortex and hippocampus (at protein level) (PubMed:29615132) . Isoform 1 is the predominant form expressed in most tissues (PubMed:16103110)

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SPHK2 Antibody (C-term) [APS00021G].

Synonyms

Sphingosine kinase 2, SK 2, SPK 2, SPHK2

Gene Name

HGNC:18859

Gene ID

56848

UniProt

Q9NRA0

Chromosomal Location

Cytoplasm. Nucleus. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JIA7}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JIA7}. Note=In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656) . In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132) . In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547) .

Applications

IHC-P-Leica, WB

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.