Vitamin K1-d4
Vitamin K1-d4 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].
Product Specifications
CAS Number
[5172-18-9]
Product Name Alternative
Phylloquinone-d4; Phytomenadione-d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
85.0
Solubility
10 mM in DMSO
Smiles
O=C1C(C)=C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(C2=C1C([2H])=C([2H])C([2H])=C2[2H])=O
Molecular Formula
C31H42D4O2
Molecular Weight
454.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Basset GJ, et al. Phylloquinone (Vitamin K1) : Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22.|[3]Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;2015:296721.|[4]Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96 (5) :1113-8.|[5]Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53 (2) :108-13.|[6]Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46 (4) :409-12.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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