STING-IN-7
STING-IN-7 is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 can inhibit the phosphorylation of STING, IRF3, and TBK1. STING-IN-7 can be used in the research of autoimmune and inflammatory diseases[1].
Product Specifications
CAS Number
[899947-07-0]
UNSPSC
12352005
Target
IKK; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sting-in-7.html
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CNC2=C1C=CC=C2)NC3=CC=C(C)C(Cl)=C3
Molecular Formula
C16H14ClN3O
Molecular Weight
299.75
References & Citations
[1]Po-Wei Chang, et al. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors. Bioorg Med Chem. 2023 Oct 14:95:117502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TBK1
Available Sizes
Curated Selection
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