Anti-Prostaglandin E Synthase Antibody

Rabbit Polyclonal Antibody specific to Prostaglandin E Synthase

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 5.3.99.3, Glutathione peroxidase PTGES, EC 1.11.1.-, Glutathione transferase PTGES, EC 2.5.1.18, Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 protein

Gene Name

PTGES

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=PTGES">PTGES</a>

UniProt

O14684

Accession Number

NP_004869.1

Cellular Locus

Membrane, Cytoplasm, perinuclear region

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH.

Target Antigen

Prostaglandin E synthase

Target

Prostaglandin E Synthase

Clonality

Polyclonal

Type

Antibody

Applications

IHC, IHC-P

Field of Research

Enzymes

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). {UniProtKB:Q9JM51, PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561}.

Additionnal Information

<br><br>Immunohistochemistry: Use at 10ug/ml.Testis: Formalin-fixed, paraffin-embedded

Storage Conditions

This antibody is stable at 4°C (short- term) and -70°C (long-term).

Specificity

This antibody recognizes an epitope near the N-terminus of human PGES.

Formulation

PBS containing 0.1% sodium azide

Target Background

Prostaglandin E Synthase (PGES) is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. PGES expression is induced by the proinflammatory cytokine IL-1B, and its activity is glutathione dependent. PGES is also expressed at high levels in p53- expressing cells.