INF4E

INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2].

Product Specifications

CAS Number

[88039-46-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/inf4e.html

Purity

99.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCOC(C(C(O)C1=C(Cl)C=CC=C1)=C)=O

Molecular Formula

C12H13ClO3

Molecular Weight

240.68

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Shi Y, et al. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021 Mar;92:107358.|[2]Mezzaroma E, et al. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules. 2021 Feb 12;26 (4) :976.|[3]occo M, et al. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57 (24) :10366-82.