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TGFβ-IN-2

TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin -induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis[1].

Product Specifications

CAS Number

2387678-02-4

UNSPSC

12352005

Target

TGF-beta/Smad

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tgfβ-in-2.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C=C1)OC2=CC(OC3=CC=CC=C32)=O)CN4CCCCC4

Molecular Formula

C22H22N2O4

Molecular Weight

378.42

References & Citations

[1]Dexin Deng, et al. Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis. Eur J Med Chem. 2020 Jan 1;185:111790.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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