MJ04
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides ‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg).
Product Specifications
CAS Number
2099014-23-8
UNSPSC
12352005
Target
EGFR; GSK-3; IGF-1R; JAK; PI3K
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mj04.html
Purity
98.08
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=C(C2=CN=C(NC=C3C4=NC(NC5CC5)=NC=C4)C3=C2)C=C1
Molecular Formula
C20H16FN5
Molecular Weight
345.37
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; GSK-3β; JAK1; JAK2; JAK3; PI3Kγ
Available Sizes
Frequently Asked Questions
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