MJ04

MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056) ‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg) [1].

Product Specifications

CAS Number

[2099014-23-8]

UNSPSC

12352005

Target

EGFR; GSK-3; IGF-1R; JAK; PI3K

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mj04.html

Purity

98.08

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC=C(C2=CN=C(NC=C3C4=NC(NC5CC5)=NC=C4)C3=C2)C=C1

Molecular Formula

C20H16FN5

Molecular Weight

345.37

References & Citations

[1]Hossain MM, et al., Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. J Transl Med. 2024 Apr 18;22 (1) :370.