HP210

HP210 is a selective glucocorticoid receptor modulator (SGRM) . HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases[1].

Product Specifications

CAS Number

[728039-52-9]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hp210.html

Purity

98.96

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(CN2C(C3=C(NC2=S)C=CS3)=O)C=C1)NC(C)C4=CC=CC=C4

Molecular Formula

C22H19N3O2S2

Molecular Weight

421.54

References & Citations

[1]Hu X, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022 Jul 5;237:114382.