ADL-5859 (hydrochloride)
ADL-5859 hydrochloride (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 hydrochloride also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 hydrochloride can be used for the research of pain[1][2].
Product Specifications
CAS Number
850173-95-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Cytochrome P450; Opioid Receptor; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/adl-5859-hydrochloride.html
Purity
98.96
Solubility
DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C2C(OC3(C=C2C4=CC=C(C=C4)C(N(CC)CC)=O)CCNCC3)=CC=C1.Cl
Molecular Formula
C24H29ClN2O3
Molecular Weight
428.95
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
δ Opioid Receptor/DOR
Available Sizes
Frequently Asked Questions
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