ADL-5859 (hydrochloride)

ADL-5859 hydrochloride (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 hydrochloride also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 hydrochloride can be used for the research of pain[1][2].

Product Specifications

CAS Number

[850173-95-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Cytochrome P450; Opioid Receptor; Potassium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/adl-5859-hydrochloride.html

Purity

98.96

Solubility

DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(OC3(C=C2C4=CC=C(C=C4)C(N(CC)CC)=O)CCNCC3)=CC=C1.Cl

Molecular Formula

C24H29ClN2O3

Molecular Weight

428.95

Precautions

H302, H315, H319

References & Citations

[1]Le Bourdonnec B, et al. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N, N-diethyl-3-hydroxy-4- (spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747) .J Med Chem. 2009 Sep 24;52 (18) :5685-702.|[2]Le Bourdonnec B, et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N, N-diethyl-4- (5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5859) . J Med Chem. 2008 Oct 9;51 (19) :5893-6.