Thiazovivin (GMP)

Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor[1].

Product Specifications

CAS Number

[1226056-71-8]

UNSPSC

12352005

Hazard Statement

H302

Target

ROCK

Type

GMP Small Molecules

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thiazovivin-gmp.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3

Molecular Formula

C15H13N5OS

Molecular Weight

311.36

Precautions

H302

References & Citations

[1]Park HS, et al. Generation of induced pluripotent stem cells without genetic defects by small molecules. Biomaterials. 2015 Jan;39:47-58. |[2]Mohseni R, et al. Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Cell Biol Int. 2015 May;39 (5) :515-8. |[3]Cheng L, et al. Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol. Front Mol Neurosci. 2017 Oct 30;10:348. |[4]Kuo HH, et al. Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture. Stem Cell Reports. 2020 Feb 11;14 (2) :256-270. |[5]Lin T, et al. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009 Nov;6 (11) :805-8.