Desipramine (hydrochloride)

Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.

Product Specifications

CAS Number

[58-28-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H317, H319, H334, H335

Target

Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/desipramine-hydrochloride.html

Purity

99.92

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl

Molecular Formula

C18H23ClN2

Molecular Weight

302.84

Precautions

H302, H315, H317, H319, H334, H335

References & Citations

[1]Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4 (1) :13-25.|[2]Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33 (13) :3190-200.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869 (5) :166700.|Br J Pharmacol. 2024 Dec;181 (23) :4874-4889.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Glia. 2022 Nov;70 (11) :2093-2107.|Inflammation. 2021 Aug;44 (4) :1592-1606.|J Parkinson Dis. 2020;10 (2) :523-542.|Neural Regen Res. 2021 Aug;16 (8) :1660-1670.|Neuroscience. 2024 Mar 26:542:11-20.|Neurotoxicology. 2022 Dec:93:173-185.|Parkinsons Dis. 2022 Nov 14:2022:1428817.|Pharmaceutics. 2022 Jul 22;14 (8) :1523.|Sci Total Environ. 2024 May 1:923:171405.|Research Square Print. 2023 Feb 23.