Gersizangitide

Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis[1][2].

Product Specifications

CAS Number

2417491-82-6

Product Name Alternative

AXT-107

UNSPSC

12352209

Target

Akt; Tie; VEGFR

Type

Peptides

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gersizangitide.html

Purity

98.05

Solubility

H2O : 33.33 mg/mL (ultrasonic)

Smiles

NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(C)C)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C111H167N29O28

Molecular Weight

2355.69

References & Citations

[1]Fei X, et al. Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration. Arch Pharm Res. 2024 Jun;47 (6) :538-557.|[2]Mirando AC, et al. A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling. JCI Insight. 2019 Feb 21;4 (4) :e122043.