α-Conotoxin Vc1.1 (TFA)

α-Conotoxin Vc1.1 TFA is a disulfide-bonded peptide isolated from Conus victoriae and is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2, α3β2 and α3β4 with IC50s of 7.2 μM, 7.3 μM and 4.2 μM, respectively, and has less inhibitory effect on other nAChR subtypes. α-Conotoxin Vc1.1 TFA has the potential for neuropathic pain reserach[1][2].

O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC[C@@H]1NC(CN)=O)([H])NC([C@@H](NC([C@@](CCC2)([H])N2C3=O)=O)CCCNC(N)=N)=O)=O)CC(N)=O)=O)CC(C=C4)=CC=C4O)=O)CC(O)=O)=O)CC5=CN=CN5)N(CCC6)[C@]6([H])C(N[C@H](C(N[C@@](C(N[C@@H](CSSC[C@](C(N[C@H](C(N[C@H]3CC(O)=O)=O)CO)=O)([H])NC1=O)C(N)=O)=O)([H])[C@@H](C)CC)=O)CCC(O)=O)=O.O=C(O)C(F)(F)F

[1]Richard J Clark, et al. The Synthesis, Structural Characterization, and Receptor Specificity of the Alpha-Conotoxin Vc1.1. J Biol Chem. 2006 Aug 11;281(32):23254-63.|[2]Narmatha Satkunanathan, et al. Alpha-conotoxin Vc1.1 Alleviates Neuropathic Pain and Accelerates Functional Recovery of Injured Neurones. Brain Res. 2005 Oct 19;1059(2):149-58.