8-Epixanthatin

8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity[1].

Product Specifications

CAS Number

[30890-35-8]

UNSPSC

12352005

Target

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-epixanthatin.html

Purity

99.61

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C=C1[C@](CC=C2/C=C/C(C)=O)([H])[C@@](OC1=O)([H])C[C@@H]2C

Molecular Formula

C15H18O3

Molecular Weight

246.30

References & Citations

[1]Yu-Jin Lee, et al. 8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generation. Phytother Res. 2021 Mar;35 (3) :1508-1520.