NLRP3-IN-56
NLRP3-IN-56 (compound 062) is a NLRP3 inhibitor. NLRP3-IN-56 potently inhibits the level of IL-1β secretion by THP-1 cells with an IC50 of 9.7 nM. NLRP3-IN-56 can be used for the study of NLRP3-mediated symptoms and/or diseases[1].
Product Specifications
CAS Number
3048421-42-4
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-56.html
Smiles
OC1=CC(Cl)=CC=C1C(N=N2)=C3C(C=C(C#CC)C=C3)=C2NC[C@H](O)CO
Molecular Formula
C20H18ClN3O3
Molecular Weight
383.83
References & Citations
[1]Fanglong Yang, et al. Pyridazine nlrp3 inhibitor compound, pharmaceutical composition, and preparation method therefor and use thereof. WO2024140824A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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