Cyproterone acetate

Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors[1][2].

Product Specifications

CAS Number

[427-51-0]

UNSPSC

12352211

Hazard Statement

H312, H332

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Cyproterone-acetate.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@]12[C@]3([H])[C@@](C(C=C1C(Cl)=C[C@]4([H])[C@]2([H])CC[C@]5([C@@]4([H])CC[C@@]5(C(C)=O)OC(C)=O)C)=O)([H])C3

Molecular Formula

C24H29ClO4

Molecular Weight

416.94

Precautions

H312, H332

References & Citations

[1]Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83 (1) : p. 136-48.|[2]Torri V, . Cyproterone acetate in the therapy of prostate carcinoma. Arch Ital Urol Androl. 2005;77 (3) :157-163.|[3]Chen L, et al. Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5. BMC Cancer. 2017;17 (1) :179. Published 2017 Mar 7.|[4]Migally N. Effect of cyproterone acetate on the structure of the adrenal cortex. Arch Androl. 1979;2 (2) :109-115.|[5]Takiguchi M, et al. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Toxicology. 2001;165 (1) :13-25.