Taccalonolide B

Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7) . Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2].

Product Specifications

CAS Number

[108885-69-4]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/taccalonolide-b.html

Purity

99.46

Solubility

DMSO : ≥ 50 mg/mL

Smiles

C[C@]1([C@]2([H])C[C@H](O3)[C@H]3[C@@H]1OC(C)=O)[C@]4([H])[C@]([C@@H](O)C2=O)([H])[C@@]5([H])[C@@](C)([C@]6([H])[C@@]([C@](C(OC7=O)=C[C@H]6C)([C@@]7(O)C)C)([H])[C@@H]5O)[C@@H](OC(C)=O)[C@H]4OC(C)=O

Molecular Formula

C34H44O13

Molecular Weight

660.71

References & Citations

[1]LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28 (15) : 1673-1675.|[2]Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68 (21) :8881-8.