Homoeriodictyol

Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo[1][2][3][4][5][6].

Product Specifications

CAS Number

[446-71-9]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Caspase; Drug Metabolite; Keap1-Nrf2; MDM-2/p53; MMP; PARP; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/homoeriodictyol.html

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C16H14O6

Molecular Weight

302.28

References & Citations

[1]Zhang M, et al. Hesperidin alleviated dendritic spines through inhibiting ferritinophagy via HERC2-NCOA4 ubiquitination in CUMS mice. Phytomedicine. 2024 Dec;135:156132.|[2]Guo P, et al. Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome. Molecules. 2022 Apr 12;27 (8) :2488.|[3]Shen T, et al. Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction. Vascul Pharmacol. 2018 Oct;109:72-82.|[4]Quaiser Saquib, et al. Anticancer efficacies of persicogenin and homoeriodictyol isolated from Rhus retinorrhoea. Process Biochemistry, ISSN: 1359-5113, Vol: 95, Page: 186-196.|[5]Al-Bzour M H, et al. Exploring the antinociceptive potential of homoeriodictyol in nociception models[J]. J. Pharm. Pharmacogn. Res, 2024, 12: 615-623.|[6]Güvenç A, et al. HOMOERIODICTYOL INHIBITS SURVIVAL AND MIGRATION OF ANDROGEN-RESISTANT PROSTATE CANCER CELLS IN VITRO. Exp Oncol. 2025 Jul 11;47 (1) :34-43.