Piperafizine B
Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) -resistant P388 cells (IC50s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model[1].
Product Specifications
CAS Number
74720-33-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Antibiotic
Type
Natural Products
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/piperafizine-b.html
Smiles
O=C(/C(NC/1=O)=C/C2=CC=CC=C2)NC1=C/C3=CC=CC=C3
Molecular Formula
C18H14N2O2
Molecular Weight
290.32
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kamei H, et al., Piperafizines A and B, potentiators of cytotoxicity of vincristine. J Antibiot (Tokyo) . 1990 Aug;43 (8) :1018-20.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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